Post by DAVID user on Jul 24, 2020 12:28:38 GMT -5
Hi,
We have been using DAVID 6.8 for Functional Annotation of gene lists. When we look at the GO_term and KEGG_pathway outputs, there are a few things about the corrected p-values that don't seem to make sense to me. First, the Bonferroni and Benjamini corrected p-vlaues are always identical. How can this be? They are two different methods for statistical correction. Second, what value is DAVID using for the Bonferroni corrections? We have had problems generating the same Bonferroni-corrected p-values when an identical gene list has been input two separate times. Also, Bonferroni correction, in my understanding, should relate back to an integer value (for the number of tests done). When I do the math on the two p-values (Bonferroni-corrected p-value/original p-value), I am getting a non-integer number. Can someone please explain these observations?
Thank you,
Glenn Doyle
We have been using DAVID 6.8 for Functional Annotation of gene lists. When we look at the GO_term and KEGG_pathway outputs, there are a few things about the corrected p-values that don't seem to make sense to me. First, the Bonferroni and Benjamini corrected p-vlaues are always identical. How can this be? They are two different methods for statistical correction. Second, what value is DAVID using for the Bonferroni corrections? We have had problems generating the same Bonferroni-corrected p-values when an identical gene list has been input two separate times. Also, Bonferroni correction, in my understanding, should relate back to an integer value (for the number of tests done). When I do the math on the two p-values (Bonferroni-corrected p-value/original p-value), I am getting a non-integer number. Can someone please explain these observations?
Thank you,
Glenn Doyle