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Post by Sakihito Kitajima on Feb 7, 2021 4:07:31 GMT -5
Hi, It is grateful if somebody could let me know what is "Fold Change" in result window, which is visible when I check "Fold Change" in options. I could not find any description in the DAVID help and manual.I speculate it is an enrichment factor, defined by the ratio of the GO term's frequency of appearance in the DEGs to its frequency of appearance in whole genome. Is it correct? Thank you.
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Brad
DAVID Bioinformatics Team
Posts: 60
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Post by Brad on Feb 17, 2021 11:37:27 GMT -5
Hello,
Thank you for bringing this to our attention. It is incorrectly labelled in the Functional Annotation Clustering options and should be labelled "Fold Enrichment" which will match the option in the Functional Annotation Chart.
"Fold Enrichment" refers to the enrichment of the term in your gene list as compared to the background population of genes.
For example, if 40/400 (i.e. 10%) of the genes from your list are involved in "kinase activity" and the background population ratio of genes involved in "kinase activity" is 300/30000 genes (i.e. 1%). There is a 10-fold(10%/1%) enrichment of genes from your list involved in "kinase activity" compared to the population.
Regards, Brad
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Post by Sakihito Kitajima on Feb 18, 2021 7:30:13 GMT -5
Thank you for reply. I understood this value is what I needed. Best regards, Sakihito Kitajima
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